• Supports inflammation reduction and helps soothe swelling
• Provides moderate anticancer support with cytotoxic and antioxidant activity
• Supports digestive comfort and reduces diarrhea
• Helps fight bacterial and fungal infections
• Supports liver health and internal cleansing
• Helps reduce fever and body heat
• Supports skin healing and topical irritation recovery
• Helps relieve mild pain and soreness
• Supports general immunity and wellness
 
 
Sandoricum koetjape, commonly known as Santol or Cottonfruit, has long been used in Southeast Asian traditional medicine. The leaves are valued for their strong anti-inflammatory, antimicrobial, fever-reducing, and digestive-supporting properties. Traditionally, leaf decoctions are used to relieve swelling, diarrhea, fever, skin irritation, and minor infections.
Modern preclinical studies show that Santol leaves possess moderate anticancer potential, with extracts demonstrating cytotoxic activity against several cancer cell lines. The leaves are also known for antimicrobial effects against bacterial and fungal strains, making them useful in traditional external and internal applications.
Traditional medicine uses the leaves for reducing inflammation, improving digestion, soothing skin problems, cleansing the liver, and reducing fever.
 
 
Top Health Benefits
(Listed in order of strongest documented effects for this plant — most effective benefits appear first)
 
1. Anti-Inflammatory Effects
One of the strongest benefits of Santol leaves; traditionally used to reduce swelling, pain, and internal heat.
 
2. Anticancer and Cellular Protection (Moderate strength)
Preclinical studies show moderate cytotoxic activity against:
Liver cancer (HepG2)
Breast cancer (MCF-7)
Cervical cancer (HeLa)
Laboratory results indicate antioxidant and antiproliferative effects.
 
3. Digestive Support
Traditionally used to reduce diarrhea, soothe digestive discomfort, and calm stomach irritation.
 
4. Antimicrobial Support
Effective in traditional use for bacterial and fungal irritation, applied internally and topically.
 
5. Liver Health & Detoxification
Traditionally used to cool the liver, cleanse toxins, and reduce internal heat.
 
6. Fever Reduction
Used as a cooling plant to lower fever and soothe heat-related symptoms.
 
7. Skin Healing Support
Applied externally to help mild skin infections, rashes, and irritation.
 
8. Mild Analgesic Effects
Traditionally used to soothe minor pain and muscle discomfort.
 
9. Immune Support
Antioxidant and antimicrobial compounds support general health and immunity.
 
 
Recommended Daily Dosage (Gelatin Capsule Form)
For cooling and antimicrobial leaf powders such as Santol:
1–2 capsules daily (400–800 mg of dried leaf powder),
taken with meals.
 
Important:
Not recommended during pregnancy.
Use cautiously with low blood pressure (mild cooling effects).
Not a substitute for cancer treatment; evidence is preclinical.